Benzodiazepines: Uses, Side Effects, and Long-Term Risks

By enhancing GABA’s effect, benzos slow down brain activity, making them effective for managing overactive brain functions that occur in anxiety, seizures, and insomnia. Benzodiazepines are a powerful medication class with a wide variety of indications and off-label uses, such as anxiety disorders, epileptic seizures, and insomnia, and for initiating anesthesia. In cases in which benzodiazepines are necessary in an older individual, the most favored options are known as the “LOT drugs” (lorazepam, oxazepam, and temazepam). This is because they are shorter-acting and do not have active metabolites, making them less likely to cause residual or longer-term side effects.

What are anti-anxiety medications?

Unlike other antidepressant medications, Exxua does not pose the risks of sexual side effects or weight gain. Some drugs can affect your blood levels of other drugs you use, which may increase side effects or make the medicines less effective. Some withdrawal symptoms may last up to 12 months or longer after stopping this medicine suddenly. Tell your doctor if you have ongoing anxiety, depression, problems with memory or thinking, trouble sleeping, ringing in your ears, a burning or prickly feeling, or a crawling sensation under your skin. Yes, benzodiazepines are sedatives that help reduce anxiety, promote sleep, and relax muscles by slowing brain activity. Benzodiazepines interact with many medications, increasing the risk of side effects list of common benzodiazepines + uses and side effects or reducing the effectiveness of other drugs.

Are benzodiazepines commonly prescribed?

  • Some benzodiazepines may be appropriate therapy in women who are breastfeeding, but only under the direction of a physician.
  • The GABA-A receptor has various subunits, and the most important in this case is the alpha (A) submit unit.
  • NIMH supports research at universities, medical centers, and other institutions via grants, contracts, and cooperative agreements.
  • Additionally, in this study, approximately 80% of patients experience withdrawal symptoms, which is much greater than the rate in other studies 65.
  • They’ll find the best treatment options available to help you feel better.

One of the study’s limitations is the inability to collect data that differentiate mortality correlation with illicit BZD use from the use of prescribed pills. Benzodiazepines are a class of drugs (commonly referred to as “benzos”) prescribed to treat anxiety, panic disorder, seizures, insomnia, and alcohol withdrawal. Drowsiness, sleepiness, or dizziness are the most common side effects reported. This can make it dangerous for people taking benzodiazepines to drive or operate machinery or perform other hazardous tasks. When discontinued, benzodiazepines should be slowly tapered to help avoid withdrawal symptoms like rebound insomnia and anxiety. The primary disadvantage of benzodiazepines is the risk of abuse, dependence, and overdose (especially with opiates).

Babies born to women who have taken barbiturates during pregnancy can be born addicted to barbiturates and suffer withdrawal symptoms. Injectable forms of barbiturates are classified as class A drugs, and oral and rectal forms as class B drugs. This means that any form of possession or supply apart from legitimately with a prescription is a punishable offense. Research indicates that the abuse of barbiturates is on the rise, especially among adolescents. They are often used to counteract the stimulant effects from drugs such as cocaine and methamphetamine. Psychotropics cover a very large group of drugs that are used to treat many different types of symptoms.

list of common benzodiazepines + uses and side effects

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Your healthcare provider can tell you more about the laws surrounding prescribing these medications and the recommended schedule for you to return for a follow-up visit. Under the direction of a physician, certain benzodiazepines may be given in very serious and life-threatening situations, like status epilepticus. Overall, benzodiazepines should be used short-term as they can lead to tolerance, abuse, dependence (addiction), withdrawal and possible fatal overdose when combined with opioids. More recent research is focusing on the possible adverse effects on cognition (thinking and reasoning ability) in patients using benzodiazepines for long periods of time.

list of common benzodiazepines + uses and side effects

5. Treatment for Benzodiazepine Withdrawal

  • The American Geriatrics Society (AGS) lists benzodiazepines as a class of medications that should be avoided in people 65 and older.
  • These neurotransmitters include serotonin, norepinephrine, and dopamine.
  • Elderly patients in intensive care can develop delirium if they are on a BZD 1.
  • As controlled substances, all benzodiazepines have the potential for abuse, addiction and diversion.

You increase your risk of developing severe sleepiness, coma, respiratory depression, and sometimes death. People respond to medications in different ways, and it may take several tries to find the medication that is most effective with the fewest side effects. In some cases, people find that a medication helps for a while and then their symptoms return. It often takes some time for a medication to work, so it is important to stick with the treatment plan and take medication as prescribed.

Too high a dose can lead to unconsciousness, breathing difficulties, and sometimes death. In the 1970s many people died after taking barbiturates, and this, together with the fact that they are extremely addictive, are the reasons they are hardly ever prescribed today. Xanax is a calming drug typically prescribed by doctors to reduce the symptoms of anxiety by acting as a sedative for the central nervous system and brain.

Does Xanax interact with my other drugs?

Some can cause very serious side effects, and healthcare professionals may set up special monitoring requirements. Psychotropic medications can be an important part of the tools available to help keep us well. Side effects include drowsiness, dizziness, confusion, and dependence with long-term use.

Results showed that, compared to wild-type mice, mice on diazepam experienced longer uninterrupted sleep 42. It also reduces the expression of mRNA transcripts such as CaMKIIa, BDNF, GIF, c-fos, NGFIa which are necessary for regulating synapses and plasticity 42. The suppression of CaMKIIa by diazepam has a long-lasting effect leading to a limited neuronal response to changes in intracellular calcium and decreased response by GABA-A receptors 42. Antipsychotic medications are prescription pharmaceuticals used to treat conditions that involve psychosis, a group of symptoms that affects the ability to tell what is real and what is not accurate. BZDs are classified as controlled substances because they have the potential for abuse and dependence. However, some medications are designated explicitly as anti-anxiety medications, such as benzodiazepines (BZDs).

According to the Drug Enforcement Administration (DEA), benzodiazepine or “benzo” drugs are depressant medications that treat anxiety, muscle spasms, and seizure disorders. Benzodiazepines may even be used in treatment and detoxification from alcohol. They are legal when a doctor prescribes them, but some people may abuse these prescriptions or buy benzos illegally. While benzos do have legitimate medical purposes, when people misuse them, they may develop a tolerance and become dependent upon them. This means that when they stop using benzos or reduce their doses, they will experience withdrawal. According to a report in Emergency Medicine News, some patients may even experience withdrawal symptoms when taking benzos under a doctor’s supervision.

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